| Candidate | Indication | Exosome Source / Route |
Discovery | Preclinical | Phase I |
|---|---|---|---|---|---|
|
EB-TM1 Exosome loaded with anti-oncogenic (KRASG12D / KRASG12C) siRNA |
PDAC | Expi293F cell / IV injection |
 |
||
| CRC | Expi293F cell / IV injection |
|
|||
|
EB-PO1 Exosome loaded with anti-inflammatory (NLRP3) siRNA |
IBD | Cow Milk / Oral administration |
 |
||
|
EB-Vac1 Exosome loaded with viral antigen protein / mRNA |
COVID-19 | aTHP-1 cell / SC injection |
 |
||
| Influenza / RSV | aTHP-1 cell / SC injection |
 |
PDAC: pancreatic ductal adenocarcinoma, CRC: colorectal cancer, IBD: inflammatory bowel disease
- Cancer
- Cancer, also called malignancy, is an abnormal growth of cells. There are more than 100 types of cancer, including breast cancer, skin cancer, lung cancer, colon cancer, prostate cancer, and lymphoma. Symptoms vary depending on the type. Cancer treatment may include chemotherapy, radiation, and/or surgery.
- Inflammatory Bowel disease (IBD)
- Inflammatory bowel disease (IBD) represents a group of intestinal disorders that cause prolonged inflammation of the digestive tract.
It is widely known for Crohn's disease and ulcerative colitis. Inflammation anywhere along the digestive tract disrupts this normal process. IBD can be very painful and disruptive, and in some cases, it may even be life-threatening.
- Vaccine
- Vaccine is a type of medicine that trains the body's immune system so that it can fight a disease it has not come into contact with
before. Typically, vaccines are against various bacterial or viral diseases.
Recently, cancer vaccine has also emerged. Cancer vaccine is an active immunotherapy to stimulate the immune system to mounta response against the tumor specific antigen and it helps the body recognize and destroy targetedcancers and may help to shrink advanced tumors.