R&D

Candidate Indication Exosome
Source / Route
Discovery Preclinical Phase I

EB-TM1

Exosome loaded with anti-oncogenic

(KRASG12D / KRASG12C) siRNA

PDAC Expi293F cell /
IV injection
CRC Expi293F cell /
IV injection

EB-PO1

Exosome loaded with anti-inflammatory

(NLRP3) siRNA

IBD Cow Milk /
Oral administration

EB-Vac1

Exosome loaded with viral

antigen protein / mRNA

COVID-19 aTHP-1 cell /
SC injection
Influenza / RSV aTHP-1 cell /
SC injection

PDAC: pancreatic ductal adenocarcinoma, CRC: colorectal cancer, IBD: inflammatory bowel disease

Cancer
Cancer, also called malignancy, is an abnormal growth of cells. There are more than 100 types of cancer, including breast cancer, skin cancer, lung cancer, colon cancer, prostate cancer, and lymphoma. Symptoms vary depending on the type. Cancer treatment may include chemotherapy, radiation, and/or surgery.
Inflammatory Bowel disease (IBD)
Inflammatory bowel disease (IBD) represents a group of intestinal disorders that cause prolonged inflammation of the digestive tract.
It is widely known for Crohn's disease and ulcerative colitis. Inflammation anywhere along the digestive tract disrupts this normal process. IBD can be very painful and disruptive, and in some cases, it may even be life-threatening.
Vaccine
Vaccine is a type of medicine that trains the body's immune system so that it can fight a disease it has not come into contact with before. Typically, vaccines are against various bacterial or viral diseases.
Recently, cancer vaccine has also emerged. Cancer vaccine is an active immunotherapy to stimulate the immune system to mounta response against the tumor specific antigen and it helps the body recognize and destroy targetedcancers and may help to shrink advanced tumors.